What is Hyaluronic Acid?

Hyaluronic acid has become one of the most famous ingredients used in the fight against ageing, present in creams and fillers alike. Hyaluronic acid is a polysaccharide present throughout the body and in the skin, and is key to maintaining skin moisture1. It has a high capacity in retaining water and regulating skin moisture1, giving youthful skin its radiance, firmness and integrity.
The loss of moisture and hyaluronic acid during the ageing process, attribute to the presence of wrinkles, sagging and the loss of suppleness for an aged appearance.

Ageing is a complex and multifactorial biological process, influenced by internal and external factors. The internal, genetic and hormonal factors affect our entire body, whereas external factors including excessive UV exposure, smoking and certain medications2 can exacerbate and accelerate the rate of change.
The loss of hyaluronic acid can be attributed to both internal and external factors.

Hyaluronic acid was originally discovered in 1934, and in the following years was found to play key functions throughout the body3. Its use in cosmetics became popular around the 90’s. It has been shown to improve skin hydration and elasticity, which can reduce the appearance of aging4.

Injectables such as Perfectha, utilise hyaluronic acid as a filler to restore volume lost with aging and to fill wrinkles. Perfectha is a range of dermal fillers, designed to treat these different signs of aging throughout the face.*

Common places to use Perfectha, dependant on the specific variant, include:
Forehead wrinkles and frown lines (glabellar lines) to fill these wrinkles
Smokers’ lines (peri-oral wrinkles) around the lips, to smooth these lines
Crow’s feet (external periocular wrinkles) around the eyes, to reduce the visibility of these lines.
Smile lines (nasolabial folds) that run along the side of the mouth from the nose, to fill these wrinkles
Lips, to give volume and better definition
Cheeks and cheekbones, to give volume and lift sagging skin in the midface
Chin and jawline, to restore a youthful contour and facial shape

*Intended uses:
Perfectha is a line of resorbable hyaluronic acid (HA) gel implants intended for reconstructive purposes in the treatment, for instance, of facial lipoatrophy, or morphological asymmetry associated with the aging process or other underlying conditions. Perfectha is for intradermal and subcutaneous application and is implanted in the areas of the face and hands to fill skin depressions and also for the augmentation of tissue volume.

1Papakonstantinou E. et al (2012) Hyaluronic acid: A key molecule in skin aging. Dermato Endocrinology 4(3): 253-258. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886/
2Nobile V, et al (2014) Anti-aging and filling efficacy of six types of hyaluronic acid based dermo-cosmetic treatment: double blind, randomized clinical trial or efficacy and safety. Journal of Cosmetic Dermatology 13(4):277-287 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371636/
3Selyanin M. A, et al. (2015) The History of Hyaluronic Acid Discovery, Foundational Research and Initial Use. Hyaluronic Acid: Preparation Properties, Application in Biology and Medicine. https://onlinelibrary.wiley.com/doi/10.1002/9781118695920.ch1
4Pavicic T, et al. (2011) Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology. 10:990-1000 https://www.ncbi.nlm.nih.gov/pubmed/22052267

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